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Layers of retina2/16/2024 The eye examination of this population-based study is led by Dr. The Principle Investigator of the LIFE Adult study is Professor Markus Loeffler, Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany. Our study sheds light on these aspects,” Rauscher said.Īll data used in the study are from the Leipzig Research Centre for Civilization Diseases-LIFE Adult study. Three dimensional ‘in-depth’ retinal imaging contains considerably more ophthalmic information than 2-D fundus imaging, and the importance of many of these additional details for understanding, diagnosing, and monitoring AMD is still unclear. In the long run, we aim to develop AMD diagnostic methods based on OCT volume scans as opposed to current clinical approaches focused on fundus images. “Therefore, we take advantage of the enriched information of retinal structure in OCT measurements by taking the spatial variation of layer thickness into consideration. However, because the retinal layer damage is typically localized, global averaging is not optimal,” Wang said, explaining the background for the study. Three-dimensional (3-D) imaging with OCT has been widely researched for opportunities to study the relationships between 3-D retinal structure and AMD, and various publications describe associations between the average thickness of retinal layers in the macula and AMD or its progression. However, the pathological changes of AMD occur deeper in the retina. “Traditionally AMD is diagnosed and staged based on fundus inspection of the macula. Considerable areas of the retinal pigment epithelium (RPE) layer were significantly thicker in eyes with late dry and wet AMD, whereas no RPE regions were significantly correlated to early or intermediate AMD, said Wang, instructor in ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear and Harvard Medical School, Boston. The thinning effect showed a parafoveal pattern, and the associations were more substantial for late dry AMD versus wet AMD.Įarly and intermediate AMD were largely associated with thicker GCL, outer plexiform layer (OPL), and IPL changes. In general, the results showed thinning of the ONL, GCL, and IPL in eyes with late dry and wet AMD. The OCT scans were machine-segmented into 10 layers, including retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), myoid zone (MZ) of the photoreceptors, ellipsoid zone (EZ) of the photoreceptors, and outer segment (OS) the photoreceptors and retinal pigment epithelium (RPE). Rauscher, PhD, at ARVO 2020.Īiming to test the hypothesis that changes in certain areas of the macular are more relevant to AMD, Wang and co-workers analyzed retinal layer thickness maps (RLTMs) and calculated pointwise partial correlations between the RLTMs and AMD stage. The impact of age-related macular degeneration (AMD) on macular retinal layer thickness is highly location-specific, according to results of a population-based study reported by Mengyu Wang, PhD, along with his collaborators Tobias Elze, PhD and Franziska G. This article was reviewed by Mengyu Wang, PhD.
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